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Int J Drug Res Clin. 2023;1: e11.
doi: 10.34172/ijdrc.2023.e11
  Abstract View: 503
  PDF Download: 409

Review Article

What is the Best Management for Geriatric Epistaxis? A Comprehensive Systematic Review and Meta-analysis

Kavous Shahsavarinia 1,2 ORCID logo, Gholamreza Faridaalaee 2 ORCID logo, Razaagh Eisazadeh Ahranjani 2, Moloud Balafar 2, Nooshin Milanchian 3 ORCID logo, Sakineh Hajebrahimi 4, Hanieh Salehi-Pourmehr 4* ORCID logo

1 Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Emergency and Trauma Care Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Islamic Azad University of Tabriz Medical Sciences, Tabriz, Iran
4 Research center for Evidence-Based Medicine, Iranian EBM Center: A Joanna Briggs Institute Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Hanieh Salehi-Pourmehr, Email: salehiha@tbzmed.ac.ir, , Email: poormehrh@yahoo.com

Abstract

Background: Given the importance of epistaxis in elder patients, this systematic review was conducted to determine the best non-surgical treatment of epistaxis in elder patients.

Methods: A systematic search of references was performed to investigate non-surgical methods in administering epistaxis in elder people in March 2022 for relevant articles.

Results: Among 1613 retrieved articles in the initial search, 28 studies were included, and the mean re-bleeding in 18 studies was 18%. Regarding the treatment methods, 35.7%, 14.3%, 10.7%, and 10.7% used nasal packing, intranasal topical tranexamic acid, silver nitrate, and Floseal® treatment, respectively. The highest success rate was related to topical tranexamic acid compared to topical oxymetazoline spray (Odds ratio [OR]: 6.50, 95% confidence interval [CI]: 1.54-27.49, P=0.011), followed by nasal compression with tranexamic acid compared to the placebo.

Conclusion: It seems that tranexamic acid has a beneficial effect on controlling epistaxis in the elderly. However, well-designed large randomized controlled trials are indicated for an accurate conclusion.


Please cite this article as follows: Shahsavarinia K, Faridaalaee G, Eisazadeh Ahranjani R, Balafar M, Milanchian N, Hajebrahimi S, et al. What is the best management for geriatric epistaxis? a comprehensive systematic review and meta-analysis. Int J Drug Res Clin. 2023;1: e11. doi: 10.34172/ijdrc.2023.e11
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Submitted: 06 Apr 2023
Revision: 18 Apr 2023
Accepted: 25 Apr 2023
ePublished: 07 Jul 2023
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