Fateme Tahmasbi
1 
, Farzin Soleimanzadeh
2 , Reza Aletaha
2 , Alireza Rahimi-Mamaghani
3* 1 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
2 Research Center for Evidence-based Medicine, Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 Clinical Research Development Unit of Tabriz Valiasr Hospital, University of Medical Sciences, Tabriz, Iran
Abstract
This comprehensive review aimed to provide an evidence-based overview of the therapeutic potential of photobiomodulation therapy (PBMT) in managing urogenital conditions. A systematic search was conducted in Web of Science, PubMed, Scopus, and Google Scholar using various MeSH terms and keywords, resulting in the identification of 8 preclinical and 14 clinical studies. The findings suggest that PBMT demonstrates promising therapeutic effects in both human studies and animal models by stimulating cellular processes and tissue repair. Although limited by poor penetration with certain devices, PBMT was found to prevent bladder cancer development and improve renal oxidative stress markers in diabetic rats. In humans, PBMT has been shown to improve sperm parameters, manage chronic pelvic diseases, alleviate pain, and enhance pelvic floor muscle strength. These findings indicate that PBMT has broad therapeutic potential for pelvic and urogenital disorders, warranting further research to clarify its mechanisms and long-term efficacy.